What is epiSAMe?
The level of epiSAMe decreases as the body ages. Concomitantly, a number of health issues, including mood, joined, and liver disorders are likely to occur.
All SAM-e molecules have two forms: the SS (active) isomer and the RS (inactive) isomer.
While epiSAMe comes in two stable salt forms; tosylate and butane disulphonate, only the tosylate form is backed by twenty years of research for safety and effectiveness.


Why Chose epiSAMe to balance hormones?
- Manufactured to the highest standards, using the original Italian method (salt - tosylate disulfate)
- SAMe products’ starting raw materials consistently test at the highest SS to RS isomer ratio on the market: SS isomer >80% / RS isomer <20%.
- Enteric coated for optimum absorption by the body
- Sealed in blister packs to ensure freshness
- Made to guaranteed purity and potency standards:
No Artifical Flavors, Dairy Free, No Preservatives, Allergen Free, No Yeast or Gluten, Kosher Certified - Have been tested for a minimum full two year stability rating
- Feed us with your health and lifestyle information to establish your personalized health ecosystem
epiSAMe
In the Spotlight
The study done by University of California showed that SAM-e is as effective as Celecoxib, a prescription drug for Arthritis.
A Korean study found that SAM-e is as effective as the NSAID Nabumetone.
The study from Massachusetts General Hospital demonstrated that SAM-e combined with antidepressants significantly increased remission rates in patients with major depression who failed conventional therapy
Arthritis Research UK study gives SAM-e the highest grade for oral supplement for osteoarthritis relief
Arthritis Today Magazine (October Issue) lists SAM-e as best supplement for osteoarthritis.
INFORMATION & RESOURCES
From the literature:
SAM-e has been shown to improve mood & emotional well being, joint health, comfort & mobility and healthy liver function in clinical studies.
In March of 2003, the AHRQ (Agency for Healthcare Research and Quality) a division of the United States Health and Human Services, released the findings of a major study on SAM-e.
SAM-e is as effective as conventional prescription medications in the treatment of depression.
SAM-e is as effective as standard prescription medications (NSAIDs) in the treatment of osteoarthritis.
SAM-e has significant benefits for patients suffering from various liver diseases. Natural SAM-e was not found to have any noticeable side effects.
Basic research on SAM-e on human cell lines and animals which were not yet followed by clinical studies
SAM-e was shown to block breast cancer growth and metastasis in experiments on breast cancer cel lines and animals.
SAM-e was shown to inhibit formation of liver cancer in rats and colorectal cancer in mice.
SAM-e was shown to block growth of prostate cancer cells.
SAM-e was shown to improve memory in a mouse model of Alzheimer disease when taken
- Rescue of Early bace-1 and Global DNA) Demethylation by S-Adenosylmethionine Reduces) Amyloid) Pathology and Improves Cognition in an Alzheimer's Model S-adenosylmethionine reduces the progress of the) Alzheimer-like features induced by B-vitamin deficiency in mice
- S-adenosylmethionine reduces the progress of the) Alzheimer-like features induced by B-vitamin deficiency in mice